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. 2017 Jul 31;36(46):6446–6461. doi: 10.1038/onc.2017.246

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Esrp2 and Esrp2-as are coordinately overexpressed in C3(1) mammary gland tumors. (a) Genomic organization of Esrp2 (dark blue) and Esrp2-as variants 1-4 (v1-4, light blue). Location of primers detecting Esrp2-as v1+2 or v1-4, respectively, is indicated in red. (b) Relative expression levels as determined by RT–qPCR are significantly different between tumor (n=11) and normal samples (n=9) for Esrp2 and Esrp2-as (v1-4), but not for Esrp2-as (v1+2). Samples were derived from animals aged 20-24 weeks, and expression levels were normalized to three reference genes (Hprt1, Tbp, β-Actin). Mann-Whitney U test, **P<0.01, ***P<0.001. (c) Esrp2 and Esrp2-as v1-4 expression assessed by RT–qPCR highly correlates in tumors, normal mammary gland, cell lines, spleen, and liver samples. Spearman’s rank correlation coefficient rho=0.88 (P <0.0001).