Fig. 3.

High porosity scaffolds enhance cell infiltration. a Experimental schematic showing fluorescently labeled tissue explant placed atop nanofibrous substrates with or without hyaluronidase (HASE) treatment. b Confocal top–down and cross-sectional views of cells (green) and corresponding nuclei (blue) within nanofibrous substrates (red). Scale = 50 µm. c Scaffold pore area fraction (n = 3 samples/group, mean ± s.d.). d Nuclear infiltration depth with schematic inset, normalized to the highly porous PCL/PEO control (n = 20 cells/group, mean ± s.e.m.). * = p < 0.05 vs. all other groups