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. 2017 Nov 24;7:16298. doi: 10.1038/s41598-017-14501-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional association between significantly regulated phosphoproteins. Visualization of functional association of significantly regulated phosphoproteins was performed using STRING database v10 at the highest confidence level of 0.900 for (A) the sample treated with 100 ng/ml of WT CyaA for 10 min and (B) for 30 min. (C) Association at medium confidence 0.400 for significantly regulated phosphoproteins in the sample treated with 100 ng/ml CyaA-AC^- toxoid. C). The software-assigned coloring of nodes has no particular meaning and many of the indicated proteins are involved in several signaling pathways in parallel. Confidence view with stronger associations is represented by thicker lines.