Table 2.
Genotype and allele frequencies of rs7763881 (A/C) and rs6983267 (G/T) polymorphisms in CRC and adenomatous polyps compared to healthy controls.
| Genotype and allele | Controls | CRC | Crude OR | P | Adjusted ORa | P a | Polyps | Crude OR | P | Adjusted ORa | P |
|---|---|---|---|---|---|---|---|---|---|---|---|
| n = 96 n (%) | n = 120 n (%) | (95% CI) | (95% CI) | n = 30 n (%) | (95% CI) | (95% CI) | |||||
| HULC rs7763881 A/C | |||||||||||
| AA | 12 (12.5) | 32 (26.7) | r | r | 6 (20) | r | |||||
| AC | 84 (87.5) | 88 (73.3) | 0.393 | 0.011 | 0.335 | 0.005 | 24 (80) | 0.57 | 0.37 | 0.512 | 0.24 |
| (0.189–0.813) | (0.157–0.716) | (0.19–1.68) | (0.166–1.58) | ||||||||
| CC | 0 (0) | 0 | — | — | — | — | 0 (0) | — | — | ||
| A | 108 (0.56) | 152 (0.63) | r | — | 36 (0.6) | r | — | ||||
| C | 84 (0.44) | 88 (0.37) | 0.744 | 0.14 | — | — | 24 (0.4) | 0.85 | 0.65 | — | — |
| (0.505–1.097) | (0.47–1.5) | ||||||||||
| rs6983267 G/T | |||||||||||
| GG | 24 (25) | 46 (38.3) | r | r | 4 (13.3) | r | r | ||||
| GT | 62 (64.6) | 56 (46.7) | 0.47 | 0.016 | 0.39 | 0.005 | 24 (80) | 2.323 | 0.2 | 2.86 | 0.09 |
| (0.256–0.869) | (0.203–0.749) | (0.729–7.4) | (0.845–9.681) | ||||||||
| TT | 10 (10.4) | 18 (15) | 0.939 | 1 | 0.863 | 0.766 | 2 (6.7) | 1.2 | 1 | 1.1 | 0.924 |
| (0.375–2.35) | (0.327–2.275) | (0.188–7.64) | (0.149–8.1) | ||||||||
| TT vs GT vs GG | 0.03 | 0.28 | |||||||||
| GT/TT | 72 (75) | 74 (61.7) | 0.536 | 0.04 | 0.47 | 0.017 | 26 (86.7) | 2.167 | 0.22 | 2.698 | 0.1 |
| (0.297–0.968) | (0.254–0.872) | (0.686–6.84) | (0.807–9.024) | ||||||||
| GG/GT | 86 (89.6) | 102 (85) | r | r | 28 (93.3) | r | r | ||||
| TT | 10 (10.4) | 18 (15) | 1.5 | 0.41 | 1.63 | 0.26 | 2 (6.7) | 0.61 | 1 | 0.564 | 0.48 |
| (0.665–3.462) | (0.698–3.804) | (0.126–2.97) | (0.113–2.8) | ||||||||
| G | 110 (0.57) | 148 (0.62) | r | — | 32 (0.53) | r | — | ||||
| T | 82 (0.43) | 92 (0.38) | 0.845 | 0.43 | — | — | 28 (0.47) | 1.174 | 0.65 | — | — |
| (0.574–1.245) | (0.655–2.1) | ||||||||||
Values are expressed as number (percentage). CI, confidence interval; r, reference. P a: adjusted for age and sex in a logistic regression model. P values in bold are statistically significant (P < 0.05).