Table 3.
Stratified analysis of the effect of rs7763881 (A/C) and rs6983267 (G/T) SNPs on CRC risk by age and sex.
| Parameter | HULC rs7763881 | P, OR (95% CI) | rs6983267 | P, OR (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AA | AC | (AC against AA) | GG | GT | TT | GT/TT | GT against GG | TT against GG | GT/TT against GG | |
| Cases/controls | Cases/controls | |||||||||
| Age, n | ||||||||||
| >50 | 14/6 | 46/30 | P = 0.605, 0.657 (0.227–1.9) | 24/6 | 30/30 | 6/1 | 36/31 | P = 0.006, 0.25 (0.089–0.698) | P = 1, 1.5 (0.15–14.94) | P = 0.02, 0.29 (0.1–0.8) |
| ≤50 | 18/6 | 42/54 | P = 0.011, 0.259 (0.094–0.716) | 22/18 | 26/32 | 12/9 | 38/41 | P = 0.41, 0.66 (0.297–1.494) | P = 1, 1.09 (0.375–3.167) | P = 0.56, 0.758 (0.353–1.627) |
| Sex, n | ||||||||||
| male | 22/6 | 58/51 | P = 0.018, 0.31 (0.117–0.825) | 32/9 | 36/38 | 12/10 | 48/48 | P = 0.003, 0.26 (0.11–0.635) | P = 0.08, 0.337 (0.11–1.03) | P = 0.002, 0.28 (0.12–0.65) |
| female | 10/6 | 30/33 | P =0.4, 0.54 (0.176-1.683) | 14/15 | 20/24 | 6/0 | 26/24 | P = 1, 0.89 (0.34-2.28) | P = 0.027 | P = 0.81, 1.16 (0.46-2.9) |
Values are expressed as numbers (cases/controls). P values in bold are statistically significant (P < 0.05).