Table 4.
Haplotype and joint analysis of rs7763881 (A/C) and rs6983267 (G/T) polymorphisms in CRC patients compared to healthy controls.
| Combined alleles | CRC, n (%) | Controls, n (%) | P | OR (95% CI) |
|---|---|---|---|---|
| AG | 182 (38) | 125 (32.5) | r | |
| AT | 122 (25) | 91 (23.75) | 0.652 | 0.92 (0.646–1.312) |
| CG | 114 (24) | 95 (24.75) | 0.318 | 0.824 (0.578–1.175) |
| CT | 62 (13) | 73 (19) | 0.012 | 0.583 (0.388–0.877) |
| Combined genotypes | ||||
| AA + GG | 12 (10) | 3 (3.13) | r | |
| AA + GT | 10 (8.33) | 9 (9.38) | 0.15 | 0.27 (0.058–1.313) |
| AA + TT | 10 (8.33) | 0 (0) | 0.25 | |
| AC + GG | 34 (28.34) | 21 (21.88) | 0.23 | 0.404 (0.1–1.6) |
| AC + GT | 46 (38.33) | 53 (55.2) | 0.024 | 0.217 (0.057–0.817) |
| AC + TT | 8 (6.67) | 10 (10.4) | 0.072 | 0.2 (0.042–0.96) |
Values are expressed in numbers. CRC, n = 120, healthy controls, n = 96. P values in bold are statistically significant (P < 0.05).