Table 1.

ICAC reduced the mortality in EV71-infected mice.

Group	Total survival rate (%)	Survival period (Days)
Control	100+	14.0*
EV71	0	7.6 ± 0.9
6.4 mg kg−1 ICAC	60+	12.5 ± 0.6*
3.2 mg kg−1 ICAC	30+	9.4 ± 1.1*
1.6 mg kg−1 ICAC	0	8.0 ± 0.6
10 mg kg−1 RBV	50+	10.1 ± 1.8*

Each 2-day-old suckling mouse was intraperitoneally challenged with EV71 (1×10⁷ TCID₅₀). Then, the infected mice were intraperitoneally injected with different daily doses of ICAC (1.6, 3.2, and 6.4 g kg⁻¹) or 10 mg kg⁻¹ of ribavirin in 0.1 mL saline for 14 days. The mice in the control (uninfected) were injected with the same volume of saline. Each group contained 10 suckling mice (n = 10). The survival rates of the mice were monitored daily. All results were expressed as the means ± SEs. Crosses and asterisks indicate that the data significantly differ from the EV71 group at the P < 0.05 level according to the Chi-square test and one-way analysis of variance, respectively.