Table 1.

Definition of the models and respective schemes for protein unfolding.

(A) Reversible two-state denaturation $N\stackrel{K}{⟷}D$	(B) Irreversible two-state denaturation $N\stackrel{k}{⟶}D$
(C) Partially reversible three-state denaturation with equilibrium $N\stackrel{K}{⟷}I\stackrel{k}{⟶}D$	(D) General partially reversible three-state model without equilibrium $N\stackrel{k_1,k_{-1}}{⟷}I\stackrel{k_2}{⟶}D$