Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 24;7:16231. doi: 10.1038/s41598-017-13431-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

ANRIL knockdown overcomes MK-induced cisplatin resistance via activation of caspase-3-dependent apoptosis. The effect of MK on the cell viability of cisplatin-treated HSC3 (a), OSCC3 (b) and SCC4 (c) cells transfected with either si-NC or si-ANRIL was determined by CCK-8 assays. Values represent the mean ± SD from three independent experiments (*P < 0.05, **P < 0.01, ***P < 0.001). The expression of PARP, Bcl-2, cleaved caspase-3 and caspase-3 in siNC- or si-ARNIL-transfected HSC3 (d), OSCC3 (e) and SCC4 (f) cell lines with either treatment of exogenous MK (100 ng/ml) or without MK was analysed by western blot. A representative experiment of four is shown. (g) A suggested mechanism for the CAF-derived MK-mediated enhancement of tumour cell resistance to cisplatin.