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. 2017 Nov 24;7:16310. doi: 10.1038/s41598-017-16429-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental protocol. The 6-day experimental protocol is described in the Methods section. Successive experimental days are shown from top to bottom on the y-axis and time-of-day is shown on the x-axis. For analysis purposes, the bedtimes and wake times of each subject were assigned a relative clock time of 00:00 and 08:00, respectively. The black rectangles represent 8-h sleep periods in darkness. The white rectangles represent waking periods during standard days in ~100 lux. The hatched rectangles represent waking periods in dim light (~3 lux). The 8-h bright light exposure is shown as white bars with sun symbols (~6,500 lux). The grey rectangles represent the constant posture (CP) procedure (~3 lux). Blood was collected hourly for 24 h during each 16-h CP procedure and the 8-h sleep period preceding or following CP1 and CP2, respectively, as indicated by grey horizontal lines. Arrows indicate times of catheter insertion (downward arrows) and removal (upward arrows).