Table 1.
Circadian phase of central and peripheral markers.
| Marker | Treatment | Condition | Phase ± SEM (h:min) (nonlinear mixed procedure) | Individual regressions (n significant/n total) |
|---|---|---|---|---|
| Cortisol | Control | Baseline | 8:24 ± 0:13 | 9/9 (100%) |
| Night shift | 7:34 ± 0:21 | 9/9 (100%) | ||
| Bright light | Baseline | 8:22 ± 0:23 | 8/8 (100%) | |
| Night shift | 17:42 ± 0:18 | 8/8 (100%) | ||
| Melatonin | Control | Baseline | 4:24 ± 0:40 | 9/9 (100%) |
| Night shift | 4:11 ± 1:12 | 9/9 (100%) | ||
| Bright light | Baseline | 4:04 ± 0:37 | 7/7 (100%) | |
| Night shift | 11:11 ± 0:33 | 7/7 (100%) | ||
| PER1 | Control | Baseline | 7:49 ± 0:13 | 8/9 (89%) |
| Night shift | 11:00 ± 0:43 | 4/9 (44%) | ||
| Bright light | Baseline | 7:46 ± 1:02 | 4/9 (44%) | |
| Night shift | 15:09 ± 1:00 | 7/8 (87.5%) | ||
| PER2 | Control | Baseline | 8:44 ± 0:39 | 4/9 (44%) |
| Night shift | 9:45 ± 1:41 | 2/9 (22%) | ||
| Bright light | Baseline | 6:06 ± 0:34 | 6/9 (67%) | |
| Night shift | 15:30 ± 0:42 | 3/8 (37.5%) | ||
| PER3 | Control | Baseline | 6:10 ± 0:18 | 8/9 (89%) |
| Night shift | 5:33 ± 0:35 | 6/9 (67%) | ||
| Bright light | Baseline | 5:22 ± 1:10 | 8/9 (89%) | |
| Night shift | 14:16 ± 1:02 | 7/8 (87.5%) | ||
| BMAL1 | Control | Baseline | 15:11 ± 0:31 | 8/9 (89%) |
| Night shift | 17:38 ± 0:52 | 5/9 (56%) | ||
| Bright light | Baseline | 21:03 ± 0:55 | 5/9 (56%) | |
| Night shift | 15:34 ± 1:44 | 3/8 (37.5%) | ||
| REV-ERBα | Control | Baseline | 2:08 ± 0:20 | 9/9 (100%) |
| Night shift | 2:32 ± 0:36 | 7/9 (78%) | ||
| Bright light | Baseline | 3:27 ± 0:33 | 6/9 (67%) | |
| Night shift | 9:49 ± 1:09 | 6/8 (75%) |