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. 2017 Nov 24;7:16222. doi: 10.1038/s41598-017-14969-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of the modulation of CrebA expression on survival of SH and DH flies. Sterile wounding and/or Pe infection were performed on 1 week old adult females of Tubulin > GeneSwith/+; UAS-CrebA ^RNAi/+ (CrebA RNAi-1; (a,b) and Tubulin > GeneSwith /+; UAS-CrebA/+ (CrebA overexpression; (b,c) genotypes in the absence (a,c: not induced) or in the presence (b,d: induced) of RU486 at indicated concentrations. Fly survival was observed up to 50 hours after treatment. (a,b) CrebA inhibition worsened the survival of SH flies but did not impact that of DH ones (see Supplementary Figure S4). (c,d) CrebA overexpression improved both DH and SH flies survival (see Supplementary Figure S4). Each group consisted of 120 flies observed among 3 different experiments (40 flies/group/experiment). Statistical analyses were performed using the Log Rank test method (**P < 0.01; ***P < 0.001). Means of survival are shown, and error bars represent standard deviations.