Table 1.
Results from statistical analyses for association between clinical characteristics and NSD1 and NSD2 (NSD) mutation status for laryngeal samples in the discovery (TCGA) and validation cohorts
| TCGA | Validation | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| NSD1/2 mutated, n = 32 | Wild type, n = 84 | p-value* | NSD1/2 mutated, n = 24 | Wild type, n = 39 | p-value* | ||||||
| n | % | n | % | n | % | n | % | ||||
| Patient Characteristics | |||||||||||
| Age, yrs Median (range) | 61.5 (38–80) | 62 (39–83) | 0.51 | 51.5 (36–86) | 65 (44–83) | <0.001 | |||||
| Age, yrs group | 0.49 | <0.001 | |||||||||
| 36–49 | 4 | 12.5 | 7 | 8.3 | 11 | 45.8 | 2 | 5.1 | |||
| 50–69 | 24 | 75.0 | 59 | 70.2 | 10 | 41.7 | 25 | 64.1 | |||
| 70–86 | 4 | 12.5 | 18 | 21.4 | 3 | 12.5 | 12 | 30.8 | |||
| Gender | 1.00 | 0.022 | |||||||||
| Female | 5 | 15.6 | 15 | 17.9 | 9 | 37.5 | 4 | 10.3 | |||
| Male | 27 | 84.4 | 69 | 82.1 | 15 | 62.5 | 35 | 89.7 | |||
| Race | 0.15 | 0.88 | |||||||||
| Black | 2 | 6.3 | 17 | 20.2 | 5 | 20.8 | 7 | 17.9 | |||
| White | 29 | 90.6 | 62 | 73.8 | 18 | 75.0 | 31 | 79.5 | |||
| Other/unknown | 1 | 3.1 | 5 | 6.0 | 1 | 4.2 | 1 | 2.6 | |||
| Smoking status | 0.34 | ||||||||||
| Current | 19 | 59.4 | 39 | 46.4 | smoking data unavailable | ||||||
| Former | 13 | 40.6 | 36 | 42.9 | |||||||
| Never | 0 | 0.0 | 6 | 7.2 | |||||||
| Unknown | 0 | 0.0 | 3 | 3.6 | |||||||
| Alcohol use | 0.75 | alcohol data unavailable | |||||||||
| Yes | 23 | 71.9 | 53 | 63.1 | |||||||
| No | 9 | 28.3 | 29 | 34.5 | |||||||
| Unknown | 0 | 0.0 | 2 | 2.4 | |||||||
| Tumor Characteristics | |||||||||||
| Clinical stage | 0.35 | 0.72 | |||||||||
| Stage I,II | 4 | 12.5 | 12 | 14.3 | 5 | 20.8 | 12 | 30.8 | |||
| Stage III | 11 | 34.4 | 16 | 19.1 | 7 | 29.2 | 7 | 18.0 | |||
| Stage IV | 16 | 5.0 | 53 | 63.1 | 10 | 41.7 | 17 | 43.6 | |||
| Stage unknown | 1 | 3.1 | 3 | 3.6 | 2 | 8.3 | 3 | 7.7 | |||
| Node status | 0.67 | 0.58 | |||||||||
| Node Neg (N0) | 18 | 58.1 | 39 | 49.4 | 12 | 54.5 | 23 | 63.9 | |||
| Any positive (N+) | 13 | 41.9 | 40 | 50.6 | 10 | 45.5 | 13 | 36.1 | |||
| Unknowna | 1 | 5 | 2 | 3 | |||||||
* p-value is from Fisher’s exact test for categorical variables or Wilcoxon rank- sum test for age (continuous)
aNodal status “unknown” excluded from comparison by mutation status