Fig. 3.
Pharmacological basis for reversal of immobility. a The serotonergic (5-HT) antagonists ritanserin (Ritan), cyproheptadine (Cypro), and metergoline (Meter) reduced immobility in the spontaneous movement assay. The data shown here were obtained with 160 μM drug. b The nonselective muscarinic cholinergic (mACh) antagonist atropine and the M1 receptor-selective antagonists pirenzepine (Pirenz) and telenzepine (Telenz) were evaluated at final drug concentrations of 2 mM (atropine) and 160 μM (pirenzepine and telenzepine). Significant stimulation of spontaneous movement in comparison to the DMSO control is indicated with asterisks (** p < 0.01).