Fig. 6.

Skeletal X-ray at the end of zoledronic acid treatment in the male proband. a Severe diaphyseal thickening and cortical sclerosis with marked reduction of the medullary cavity of both femurs, radii and ulnae. Bilateral coxa valga with subluxation of femoral neck. b Severe diaphyseal thickening and cortical sclerosis with marked and irregular reduction of the medullary cavity of both tibiae and fibulae. c Thickening and cortical sclerosis with reduction of the medullary cavity, mainly at the distal end of the diaphysis, in the right humerus. White circles show the typical multiple zebra lines due to the intravenous bisphosphonates infusions.