Fig. 8.

Serum levels of osteocalcin (a), procollagen type I N-terminal propeptide (PINP) (b), and carboxyterminal telopeptide of type I collagen (ICTP) (c) before (0) and during bisphosphonate treatment. The female proband (white circles) was treated with zoledronic acid. The male proband (black circles) was treated with 4 cycles of neridronic acid (1–4) followed by 4 cycles of zoledronic acid (5–8). Gray area: normal range for female proband (reference for young adults). Lined light-gray area: normal range for male proband (reference for prepubertal children, own laboratory).