Table 2.
Influenza Vaccination and Severity of Influenza Disease Analysis for Cases Treated With Antivirals by Age Category, After Propensity Score Matching (n = 1509)a
Clinical Outcomes | Influenza Vaccine 2012–13 Season | |||||
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50–64 y (n = 494) | 65–74 y (n = 495) | ≥75 y (n = 520) | ||||
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Point Estimate (95% CI) | P Value | Point Estimate (95% CI) | P Value | Point Estimate (95% CI) | P Value | |
Severe diseaseb (OR) | 0.97 (.62; 1.52) | .89 | 1.27 (.81; 1.99) | .29 | 0.99c (.59; 1.66) | .97 |
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Diagnosis of pneumoniad (OR) | 0.79 (.54; 1.18) | .25 | 0.86c (.59; 1.26) | .44 | 0.94c (.65; 1.35) | .72 |
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ICU length of stay (RH)e | 1.25 (.82; 1.91) | .3 | 1.60 (1.04; 2.46) | .03 | 0.94 (.50; 1.77) | .85 |
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Length of hospital stay (RH)e | 1.03 (.88; 1.21) | .69 | 1.03 (.88; 1.21) | .68 | 1.02 (.87; 1.19) | .80 |
Abbreviations: BMI, body mass index; CI, confidence interval; ICU, intensive care unit; OR, odds ratio; RH, relative hazard.
Variables used for propensity score matching: sex, race, BMI, medical condition (asthma, chronic lung disease, cardiovascular disease, chronic metabolic disease, neurologic disease, immunosuppression, hemoglobinopathy/blood disorders, renal disease, liver disease), alcohol abuse, and smoking.
Admitted to ICU or deceased.
Adjusted for the Charlson score.
Among those who had a chest X-ray taken within 3 days of admission (n = 1,460).
RH represents ICU or hospital discharge accounting for death as a nonindependent competing risk.