Table 1.

Clonotypes identified with HashClone analysis and IMGT validation

			Phase A	Phase B
Study	Patient	Clonotype	Clonotype with	Clonotype with
	(only diagnosis samples)	identified	frequency >100	VDJ homology >80%
Pilot 1	A	1616	12	7
	B	1703	59	33
	C	2149	72	44
	D	870	10	5
	E	1398	35	21
	Average value	1547	38	22
Pilot 2	A	96	18	6
	B	278	72	11
	E	77	5	0
	Average value	150	32	6

For each patient of both Pilot studies the total number of identified clonotypes (third column) is reported. The number of clonotypes with a frequency greater than 100 were selected and passed the Phase A are reported in fourth column. Then from the Phase A, clonotypes with a VDJ homology greater than 80% were selected and passed the Phase B (fifth column). The average value are reported in bold