Table 4.
Significantly expressed A. niger N402 genes from cluster B in the expression profiling tree
| Up/Down-regulatedc | Regulated by | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Genea | Enzymeb | CAZy family | ΔxlnR | ΔaraR | ΔrhaR | ΔgalX | ΔamyR | This study | Literature | Reference | |
| B-1 | An03g01050 | GLN | GH5 | 4.8 | −74.6 | 3.1 | 29.9 | 6.3 | AraR | nr | [38] |
| An14g01800 (aglD) | AGL | GH27 | −1.5 | −97.4 | – | – | – | AraR | nr | [38] | |
| An01g00330 (abfA) | ABF | GH51 | 1.0 | −113.9 | −1.7 | 4.6 | 38.3 | AraR | AraR, GaaR | [15, 22, 34, 68] | |
| An03g00940 (xlnC/xynA) | XLN | GH10 | −17.6 | −27.6 | – | – | – | AraR, XlnR | ClrA, XlnR | [13, 21, 38] | |
| An03g00960 (axhA) | AXH | GH62 | −17.3 | −28.5 | – | – | – | AraR, XlnR | AraR, XlnR | [21, 22, 30] | |
| An16g06800 (eglB) | EGL | GH5 | 4.1 | −6.2 | −1.3 | −1.1 | 1.0 | AraR | nr | [38] | |
| An15g04550 (xynA) | XLN | GH11 | – | −6.6 | – | – | – | AraR | nr | [38] | |
| B-2 | An12g05010 (axeA) | AXE | CE1 | −51.5 | 1.5 | – | – | – | XlnR | XlnR | [21, 38] |
| An01g09960 (xlnD/xynD) | BXL | GH3 | −502.6 | 1.6 | −1.8 | 2.1 | 5.9 | XlnR | XlnR | [21, 69] | |
| An08g01900 | BXL | GH43 | −4.0 | 1.2 | – | – | – | XlnR | nr | [38] | |
| An11g02100 | BGL | GH1 | −5.3 | 2.0 | 1.0 | 2.1 | 2.0 | XlnR | nr | [38] | |
| An14g05800 (aguA) | AGU | GH67 | −32.5 | 2.1 | −3.7 | 1.5 | 1.5 | RhaR, XlnR | XlnR | [21, 70] | |
| An09g00120 (faeA) | FAE | SF7d | −78.3 | −1.5 | – | – | – | XlnR | XlnR | [21, 36] | |
| An08g01760 | CBH | GH6 | −3.8 | – | – | – | – | XlnR | nr | [38] | |
| An09g03300 (axlA/xylS) | AXL | GH31 | −10.4 | −6.3 | 1.3 | 3.8 | 4.3 | AraR, XlnR | nr | [41] | |
| An01g00780 (xlnB/xynB) | XLN | GH11 | −40.7 | −5.6 | 1.7 | 1.1 | −2.2 | AraR, XlnR | XlnR | [21, 38] | |
aGenes with expression value of <50 in all studied A. niger N402 cultures are not included in the table
bEnzyme codes are provided in Additional file 2
cFold-change between A. niger N402 and the regulatory mutants grown on their relevant carbon source. - = expression value <50 in both N402 and regulatory mutant strain. Negative fold-changes >2.5 were considered as proof of regulator function and are depicted in bold
dSub-family (SF) classification of fungal FAEs according to Dilokpimol et al. [49]
nr not reported