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. 2017 Nov 23;12:98. doi: 10.1186/s13019-017-0668-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Case 2. Chest CT showing a primary lesion in the right lower lobe (a), a 10-mm nodule in the right S6, and right middle lobe atelectasis due to bulky hilar and subcarinal lymph nodes (b) before afatinib treatment. Chest CT showing the marked regression of both the primary tumor (c) and lymph node metastases, with the disappearance of middle-lobe atelectasis (d) after afatinib therapy. Histological findings (hematoxylin-eosin staining) showing the prominent proliferation of fibroblasts (e); residual viable tumor cells were found in a small area of the primary lesion (f)