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. 2017 Nov 23;9:91. doi: 10.1186/s13195-017-0319-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Plasma biomarkers associated with longitudinal changes in NPI-agitation/aggression scores based on the differences in ApoE4 carrier status. a Compared with the Aβ1–42/Aβ1–40 ratios in the low tertile, those in the high tertile were associated with a significant increase in NPI-agitation/aggression scores in ApoE4-positive carriers based on a GEE analysis adjusted for age, gender, and years of education (p = 0.02). b There was no significant difference between groups for NPI-agitation/aggression scores in ApoE4-negative carriers based on a GEE analysis adjusted for age, gender, and years of education. Data are presented as the mean ± standard error. Aβ amyloid beta peptide, AD Alzheimer’s disease, NPI Neuropsychiatric Inventory