Fig. 3.

Binding of serum IgG to non-pTau peptide in NCI, MCI, and AD subjects. Means (circle), medians (line through center of box), upper and lower quartiles (upper and lower borders of box, respectively), most extreme non-outlier values (lines extending from box), and outliers (asterisks) are shown for non-pTau IgG ratios in serum samples from NCI, MCI, and AD subjects. “non-pTau IgG ratio” is the ratio of a serum sample’s IgG binding to non-phosphorylated tau peptide-coated wells divided by its IgG binding to $\mathrm{BSA}‐\text{coated wells}:\frac{\mathrm{OD}\text{for}\mathrm{IgG}\text{binding to non}‐\text{pTau peptide}}{\mathrm{OD}\text{for}\mathrm{IgG}\text{binding to}\mathrm{BSA}}$ The p-value for the between-group differences for the antibody ratios was 0.052. (NCI = no cognitive impairment; MCI = mild cognitive impairment; AD = Alzheimer’s disease; non-pTau IgG = specific IgM binding to non-phosphorylated tau 196-207)