Table 2.
pTau IgG | non-pTau IgM | pTau IgM | Age | Global Cognition | NFT counts | |
---|---|---|---|---|---|---|
Non-pTau IgG | −0.14 | −0.01 | 0.12 | 0.55 | −0.50 | 0.14 |
0.47 | 0.95 | 0.51 | 0.002 | 0.005 | 0.46 | |
pTau IgG | −0.11 | 0.08 | 0.09 | 0.13 | 0.20 | |
0.57 | 0.69 | 0.62 | 0.49 | 0.30 | ||
non-pTau IgM | −0.62 | −0.08 | 0.05 | 0.24 | ||
0.0002 | 0.66 | 0.81 | 0.20 | |||
pTau IgM | 0.23 | −0.05 | −0.13 | |||
0.22 | 0.78 | 0.50 |
Correlations in pooled data from all subjects are shown as Spearman’s rho values (top line) and their associated p-values (bottom line). The pTau IgM and non-pTau IgM ratios were negatively correlated, as were global cognitive functioning scores and the non-pTau IgG ratio. Subject age was positively associated with the non-pTau IgG ratio. (NFT = neurofibrillary tangles; pTau IgG = ratio of IgG binding to tau 196-207 phosphorylated at Serine-199 and Serine-202; non-pTau IgG = ratio of IgG binding to non-phosphorylated tau 196-207; pTau IgM = ratio of IgM binding to tau 196-207 phosphorylated at Serine-199 and Serine-202; non-pTau IgM = ratio of IgM binding to non-phosphorylated tau 196-207)