Table 3. Summary of schedule for Tissue response RCT.

	What will happen?	Is this visit combined with usual hospital treatment?
Medical check-up Approx. 1–2 hours.	Eligibility assessment including chest X-ray and blood tests.	Yes, combined with pre-operation assessment
Injection visit Approx. 2 hours.	•  Dupuytren’s assessment        •  Blood test        •  Ultrasound scan        •  Hand photo        •  EQ-5D-5L Questionnaire        •  Nodule hardness        •  Injection and then assessment of injection site	No
Surgery day Approx. 1 hour.	•  Assessment of injection site        •  Blood test        •  Ultrasound scan        •  Hand photo        •  Nodule hardness	Yes, while waiting for surgery
2 weeks after surgery Approx. 20 mins.	•  Surgery site assessment.        •  Hand photo	Yes, combined with surgery aftercare
12 weeks after surgery Approx. 15 mins.	•  EQ-5D-5L Questionnaire        •  Review of therapy record	Yes, combined with surgery aftercare