Table 5. Summary of schedule of events for early DD RCT.

	What will happen?
Medical check-up Approx. 1-2 hours.	Eligibility assessment including chest X-ray and blood tests.
Injection visit 1 Approx. 2 hours.	• Dupuytren’s assessment        • Blood test        • Ultrasound scan        • Hand photo        • EQ-5D-5L and hand function questionnaires        • Resource use questionnaire        • Nodule hardness, finger movement and grip strength        • Injection and then assessment of injection site
Injection visit 2 3 months after first injection Approx. 2 hours.	• Assessment of nodules and cords in hand        • Blood test        • Ultrasound scan        • Hand photo        • EQ-5D-5L and hand function questionnaires        • Resource use questionnaire        • Nodule hardness, finger movement and grip strength        • Injection and then assessment of injection site
Injection visit 3 and 4 6 and 9 months later Approx. 2 hours.	• As at 3 months but without blood test
12 months later Approx. 1 hour.	• As at 3 months but without injection
18 months later Approx. 1 hour.	• As at 3 months but without injection or blood test