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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Nat Immunol. 2017 Aug 28;18(10):1084–1093. doi: 10.1038/ni.3821

Figure 4.

Figure 4

The protective effect of IFN-λ in DSS-induced colitis is independent of the genetic background or strain-specific microbiota. Colitis in wild-type mice left treated with various combinations (keys and axes) of 2.5% DSS in their drinking water (DSS) or not (− DSS) and daily intraperitoneal injection of antibody to IFN-λ (α-IFN-λ) (10 g/kg) or not (no Ab), assessed as body weight (a), colon length (b), histopathological score (c) and histology (d). Scale bars (d), 500 μm. *P < 0.05, **P < 0.01 and ***P < 0.001 (two-way ANOVA (a,b) or nonparametric two-tailed t-test (c)). Data are from one experiment representative of three independent experiments (mean + s.e.m. of five mice in a–c).