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. 2017 Nov 10;11:628. doi: 10.3389/fnins.2017.00628

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Copyright © 2017 Al-Gharaibeh, Culver, Stewart, Srinageshwar, Spelde, Frollo, Kolli, Story, Paladugu, Anwar, Crane, Wyse, Maiti, Dunbar and Rossignol.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Transplanted iPS-NSCs survived and differentiated into mature neurons and medium spiny neurons in HD mice. Confocal images were captured from iPS-NSCs treated HD mouse. Hoechst labeled iPS-NSCs (blue) were found in striata 10 weeks post transplantation. Also, Hoechst labeled iPS-NSCs (blue) show co-expression of mature neurons marker (NeuN; green) and region specific neurons (DARPP-32; red). (B) Proportion of Hoechst labeled iPS-NSCs that are co-labeled with DARPP-32 is significantly higher in HD+iPS-NSCs mice compared to WT+iPS-NSCs (p = 0.029). (C) Proportion of Hoechst labeled iPS-NSCs that are co-labeled with NeuN is significantly higher in HD+iPS-NSCs mice compared to WT+iPS-NSCs (p = 0.038). ^*Significant different, p < 0.05.