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. 2017 Nov 10;8:894. doi: 10.3389/fphys.2017.00894

Figure 1.

Figure 1

Effects of CXL-1020 on systemic, energetic, and left-ventricular hemodynamic indices in instrumented normal anesthetized rats. (A) Percent change vs. baseline following 30 min of continuous IV infusion of CXL-1020 (100 μg/kg/min, n = 31). (B) Schematic of the experimental design with black block indicating data acquisition. (C) Representative PV loops and % change from baseline comparing CXL-1020 (n = 7) to volume matched vehicle control (7% Captisol, n = 8) (D) before and (E) during volume expansion with Hextend (~1–1.5 mL). (F) Representative PV loops and % change from baseline comparing CXL-1020 (n = 7) to SNP (25 μg/kg/min, n = 6) (G) before and (H) during afterload restoration with PE (5 μg/kg/min). *P < 0.05 vs. corresponding baseline.