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. 2017 Nov 10;8:894. doi: 10.3389/fphys.2017.00894

Figure 2.

Figure 2

Effects of clinically established drugs and CXL-1020 when administered in combination on estimated mechanical energy and LV hemodynamics indices in instrumented anesthetized normal rats. Summary data as % change from baseline of CXL-1020 administered with an (A) ACE inhibitor, (ENA, 1 mg/kg/hr, n = 5), (B) β-AR blocker, MET (1 mg/kg/h, n = 7), and β-AR 1 agonist, DOB (5 μg/kg/min, n = 7). Experimental design schematic with black block indicating data acquisition is below each corresponding graph. *P < 0.05 vs. corresponding baseline, #P < 0.05 vs. corresponding CXL-1020 alone.