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. 2017 Nov 10;8:894. doi: 10.3389/fphys.2017.00894

Figure 3.

Figure 3

Effect of CXL-1020 on systemic and LV hemodynamics indices in instrumented anesthetized RW and ISO rat models. (A) Echocardiographic evaluation on systolic and diastolic indices in RW (n = 15) and ISO rats (n = 6). (B) Cardiovascular profiles of CXL-1020 (100 μg/kg/min, n = 8) as shown as % change from baseline following 5 weeks of renal wrapping. (C) Representative single PV loop of the diastolic portion. (D) Cardiovascular profile of CXL-1020 (100 μg/kg/min, n = 6) as shown as % change from baseline following 4 weeks of chronic ISO. (E) Representative single PV loop of the diastolic portion. Experimental design schematic with black block indicating data acquisition is below each corresponding graph. *P < 0.05 vs. corresponding baseline.