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. 2017 Nov 10;8:894. doi: 10.3389/fphys.2017.00894

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Copyright © 2017 Roof, Ueyama, Mazhari, Hamlin, Hartman, Ziolo, Reardon and del Rio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of CXL-1020 and MIL effects on systemic and LV hemodynamic indices in instrumented anesthetized rats and cardiomyocyte function. Summary data comparing as % change from baseline of (A) Tau (n = 6) and (B) myocyte function (n = 14–17 cells/7–8 hearts) in ISO rats. (C) Summary data as % change from baseline of a dose response of CXL-1020 and MIL in normal rats on contractile changes (CaT and shortening amplitude) and (D) relaxation (CaT and relengthening RT50), 7–25 cells/5–8 hearts. (E) Summary data as % change from baseline of CXL-1020 and MIL on heart rate in normal, RW and ISO rats (n = 5–7). (F) The time course of ectopic beats/per minute from the LV-pressure curve during IV infusion (n = 12–13). ^*P < 0.05 vs CXL-1020.