Table 3.
Effects of clinically established drugs on estimated mechanical energy and LV hemodynamics indices in instrumented anesthetized normal rats.
| Parameters | Drug | Normal | ||
|---|---|---|---|---|
| Baseline | Drug | % Δ frombaseline | ||
| HR (bpm) | SNP | 385 ± 10 | 394 ± 8 | 3 ± 2 |
| DOB | 354 ± 9 | 436 ± 16* | 24 ± 5 | |
| MAP (mmHg) | SNP | 116 ± 7 | 80 ± 7* | −32 ± 3 |
| DOB | 114 ± 5 | 114 ± 5 | 0 ± 4 | |
| PVA (mmHg * RVU * 103) | SNP | 2.7 ± 0.6 | 2.9 ± 0.6* | −22 ± 10 |
| DOB | 3.9 ± 0.6 | 5.9 ± 1.0* | 54 ± 19 | |
| PRSW (mmHg) | SNP | 75 ± 13 | 76 ± 19 | −4 ± 7 |
| DOB | 48 ± 5 | 99 ± 13* | 110 ± 19 | |
| EDPVR (mmHg/RVU) | SNP | 1.8 ± 0.4 | 1.6 ± 0.8 | 0 ± 17 |
| DOB | 2.6 ± 0.6 | 1.8 ± 0.4* | −30 ± 5 | |
Summary data as values are mean ± standard error of the mean and % change from baseline of sodium nitroprusside (SNP) (25 μg/kg/min, n = 6), dobutamine (DOB) (5 μg/kg/min, n = 7).
*
P < 0.05 vs. corresponding baseline.