Table 5.

Effect of CXL-1020 on LV on systolic and diastolic functional indices via an echocardiographic evaluation in anesthetized RW and ISO rat models.

Parameters	Model/Timepoint	Value ± SEM	% Δ from baseline
EF	Baseline	74 ± 2	–
	RW−2 week	76 ± 1	3 ± 1
	RW−4 week	75 ± 1	2 ± 1
	ISO−4 week	65 ± 1	−12 ± 2*
E/A ratio	Baseline	2.1 ± 0.1	–
	RW−2 week	1.9 ± 0.1	−12 ± 3*
	RW−4 week	1.7 ± 0.1	−23 ± 2*
	ISO−4 week	1.35 ± 0.03	−37 ± 1*
IVRT (ms)	Baseline	25 ± 1	–
	RW−2 week	34 ± 1	33 ± 4*
	RW−4 week	38 ± 1	50 ± 4*
	ISO−4 week	47 ± 3	86 ± 10*

Summary data as values are mean ± standard error of the mean and % change from baseline; n = 6–15.

^*P < 0.05 vs. baseline.