Table 6.

Cardiovascular activity of CXL-1020 in instrumented anesthetized RW and ISO rats.

Parameters	Model	Baseline	CXL-1020	% Δ from baseline
HR (bpm)	Normal	352 ± 16	353 ± 17	0 ± 1
	RW	389 ± 9	390 ± 9	0 ± 1
	ISO	324 ± 10	324 ± 14	0 ± 2
MAP (mmHg)	Normal	128 ± 5	95 ± 5*	−26 ± 2
	RW	141 ± 5	97 ± 6*	−23 ± 4
	ISO	132 ± 4	97 ± 6*	−26 ± 4
LV–EDP (mmHg)	Normal	4.1 ± 1.1	2.4 ± 1.4*	−60 ± 13
	RW	15.1 ± 2.0	9.7 ± 2.0*	−40 ± 9
	ISO	14.1 ± 1.6	7.8 ± 2.7*	−53 ± 15
ESPVR (mmHg/RVU)	Normal	19.5 ± 1.7	26.1 ± 1.1*	37 ± 8
	RW	20.4 ± 1.4	26.3 ± 1.9*	29 ± 5
	ISO	16.3 ± 2.2	20.4 ± 2.5*	26 ± 5
PRSW (mmHg)	Normal	42 ± 1	53 ± 1*	26 ± 1
	RW	44 ± 2	59 ± 4*	33 ± 6
	ISO	32 ± 1	45 ± 1*	40 ± 5#
EDPVR (mmHg/RVU)	Normal	1.4 ± 0.1	1.0 ± 0.1*	−29 ± 5
	RW	2.8 ± 0.5	1.2 ± 0.3*	−60 ± 5#
	ISO	4.3 ± 0.6	1.6 ± 0.3*	−63 ± 2#
LV–Tau (ms)	Normal	8.9 ± 0.5	7.6 ± 0.4*	−14 ± 1
	RW	9.9 ± 0.3	8.3 ± 0.3*	−16 ± 2
	ISO	14.3 ± 1.0	10.5 ± 0.8*	−27 ± 1#
LV–Tauc (%)	Normal	5.4 ± 0.2	4.7 ± 0.1*	−12 ± 1
	RW	6.4 ± 0.3	5.4 ± 0.2*	−16 ± 1
	ISO	7.7 ± 0.3	5.6 ± 0.2*	−27 ± 1#

Changes in systemic and LV hemodynamics indices, and LV mechanical parameters were measured at baseline, and following 30 min of continuous IV infusion of CXL-1020 (100 μg/kg/min, n = 7 Normal, n = 6 ISO, n = 7 RW). Summary data as values are mean ± standard error of the mean and % change from baseline.

^*P < 0.05 vs. baseline,

^#P < 0.05 vs. corresponding normal.