Table 9.
Effects of L-Type Ca2+ Channel blockade on systemic and LV hemodynamics indices in instrumented anesthetized normal rats.
| Parameters | Drug | Normal | ||
|---|---|---|---|---|
| Baseline | Drug | % Δ from baseline | ||
| LV–Tau (ms) | VER | 8.7 ± 0.2 | 8.7 ± 0.4 | 0 ± 3 |
| CXL-1020 | 8.7 ± 0.5 | 7.3 ± 0.4 | −16 ± 4* | |
| CXL-1020 + VER | – | 7.3 ± 0.4 | −16 ± 4* | |
| MIL | 8.4 ± 0.5 | 6.6 ± 0.4 | −20 ± 3* | |
| MIL + VER | – | 6.2 ± 0.6 | −26 ± 6* | |
| HR (bpm) | VER | 365 ± 5 | 363 ± 6 | −1 ± 1 |
| CXL-1020 | 358 ± 10 | 346 ± 8 | −3 ± 2 | |
| CXL-1020 + VER | – | 347 ± 4 | −3 ± 3 | |
| MIL | 340 ± 8 | 349 ± 8 | 3 ± 1 | |
| MIL + VER | – | 340 ± 8 | −1 ± 2 | |
| MAP (mmHg) | VER | 134 ± 3 | 111 ± 4 | −17 ± 2* |
| CXL-1020 | 115 ± 6 | 84 ± 7 | −27 ± 4* | |
| CXL-1020 + VER | – | 71 ± 3 | −37 ± 3* | |
| MIL | 117 ± 6 | 81 ± 6 | −31 ± 2* | |
| MIL + VER | – | 52 ± 3 | −55 ± 1* | |
| PRSW (mmHg) | VER | 56 ± 5 | 47 ± 4 | −15 ± 4* |
| CXL-1020 | 54 ± 5 | 69 ± 6 | 29 ± 7* | |
| CXL-1020 + VER | – | 64 ± 6 | 21 ± 5* | |
| MIL | 48 ± 7 | 70 ± 10 | 34 ± 9* | |
| MIL + VER | – | 39 ± 3 | −16 ± 9 | |
Changes were measured at baseline, and following 30 min of continuous IV infusion of verapamil (VER) alone, CXL-1020 (100 μg/kg/min, n = 7) and MIL (10 μg/kg/min, n = 7) with and without VER,
*
P < 0.05 vs. corresponding baseline.