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. 2017 Nov 21;12:8325–8336. doi: 10.2147/IJN.S147506

Figure 7.

Figure 7

Biocompatibility and cytotoxicity of the (A) blank and 5-FU-loaded SLNs against HGF cells after 24 hours and (B) 5-FU-loaded SLNs against breast cancer cells (MDA-MB-231) after 1 hour at 37°C and 39°C (data = mean ± SD, n=3).

Note: (B) 37 and 39 represent temperature (°C) of drug release studies.

Abbreviations: 5-FU, 5-fluorouracil; SLN, solid lipid nanoparticle; HGF, human gingival fibroblast; FLOM, 5-FU-loaded lauric acid and oleic acid nanoparticles prepared with mono-surfactant system; FLOD, 5-FU-loaded lauric acid and oleic acid nanoparticles prepared with double-surfactant system; FLLD, 5-FU-loaded lauric acid and linoleic acid nanoparticles prepared with double-surfactant system; LOM, lauric acid and oleic acid nanoparticles prepared with mono-surfactant system; LOD, lauric acid and oleic acid nanoparticles prepared with double-surfactant system; LLD, lauric acid and linoleic acid nanoparticles prepared with double-surfactant system.