Table 1.
Composition and properties of SLNs
| Formulation code | Lipid mixture | Surfactant | 5-FU (mg) | Size (nm) | PDI | Zeta potential | EE (%) |
|---|---|---|---|---|---|---|---|
| FLOM | LO | Brij 58 | 5 | 120 | 0.2 | −34.0 | 42.32 |
| FLOD | LO | Brij 58:Span 80 | 5 | 198 | 0.2 | −36.2 | 40.36 |
| FLLMa | LL | Brij 58 | 5 | – | – | – | – |
| FLLD | LL | Brij 58:Span 80 | 5 | 158 | 0.1 | −40.5 | 40.12 |
Notes:
a
FLLM was unstable and immediately formed a gel-like phase. Therefore, its characterization was not performed.
Abbreviations: SLN, solid lipid nanoparticle; 5-FU, 5-fluorouracil; PDI, polydispersity index; EE, encapsulation efficiency; FLOM, 5-FU-loaded lauric acid and oleic acid nanoparticles prepared with mono-surfactant system; LO, lauric acid and oleic acid; FLOD, 5-FU-loaded lauric acid and oleic acid nanoparticles prepared with double-surfactant system; FLLM, 5-FU-loaded lauric acid and linoleic acid nanoparticles prepared with mono-surfactant system; LL, lauric acid and linoleic acid; FLLD, 5-FU-loaded lauric acid and linoleic acid nanoparticles prepared with double-surfactant system.