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. 2017 Nov 2;8:2153. doi: 10.3389/fmicb.2017.02153

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Copyright © 2017 Yang, Sun, Zhang, Liu and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Active compound No.3A5 disrupt the interaction between NS3h and nucleic acids. (A) EMSA. Samples were examined on a 15% native polyacrylamide gel. Lane 1, Cy5-dT20 only; lane 2, Cy5-dT20, NS3h and DMSO; lane 3, Cy5-dT20, NS3h and 50 μM aurintricarboxylic acid; lane 4, Cy5-dT20, NS3h and 1 mM compound No.3A5. (B) In ATPase assays, addition of dT20 enhanced ATP hydrolyzation. (C) Increasing amount of compound No.3A5 could affect ATPase of NS3h. (D) Inhibition results showed compound No.3A5 had no binding selectivity on NS3h. (E) Inhibition results showed compound No.3A5 had no binding selectivity on SSB protein of Escherichia coli.