FIGURE 3.

Effect of α₁-adrenergic receptor stimulation on the membrane potential of layer V mPFC pyramidal neurons. (A) Membrane potential recorded during bath application of phenylephrine (100 μM, a). Amplitude of the membrane potential change evoked by 100 μM phenylephrine (phenylephrine, b). (B) Membrane potential change evoked by bath application of cirazoline (100 μM, a). Amplitude of the membrane potential change evoked by 100 μM cirazoline (cirazoline, b). (C) Membrane potential change evoked by bath application of cirazoline (100 μM) in the presence of prazosin (100 μM in the bath, a). Amplitude of the membrane potential change evoked by 100 μM cirazoline alone (cirazoline) and 100 μM cirazoline in the presence of 100 μM prazosin (+ prazosin, b). (D) Membrane potential change evoked by bath application of cirazoline (100 μM) in the presence of efaroxan (100 μM in the bath, a). Amplitude of the membrane potential change evoked by 100 μM cirazoline alone (cirazoline) and 100 μM cirazoline in the presence of 100 μM efaroxan (+ efaroxan, b); ^∗∗∗p < 0.001; n.s., non-significant. Continuous horizontal bars below the recording traces indicate the bath/extracellular solution presence of the compounds in this and other figures.