Skip to main content
. 2017 Nov 2;11:341. doi: 10.3389/fncel.2017.00341

FIGURE 5.

FIGURE 5

Effect of selective β-adrenergic receptor blockers on NA-induced depolarization (A,B) and the inward current (C,D) in layer V mPFC pyramidal neurons. (A) Depolarization evoked by bath application of NA (50 μM) in the presence of the selective β1-adrenergic receptor blocker metoprolol (60 μM in the bath, a). Amplitude of the membrane potential change evoked by 50 μM NA alone (NA) and 50 μM NA in the presence of 60 μM metoprolol (+ metoprolol, b). (B) Depolarization evoked by bath application of NA (50 μM) in the presence of the selective β2-adrenergic receptor blocker ICI 118551 (50 μM in the bath, a). Amplitude of the membrane potential change evoked by 50 μM NA alone (NA) and 50 μM NA in the presence of 50 μM ICI 118551 (+ ICI 118551, b). (C) Inward current evoked by bath application of NA (50 μM) in the presence of the selective β1-adrenergic receptor blocker metoprolol (60 μM in the bath, a). Amplitude of the holding current change evoked by 50 μM NA alone (NA) and 50 μM NA in the presence of 60 μM metoprolol (+ metoprolol, b). (D) Inward current evoked by bath application of NA (50 μM) in the presence of the selective β2-adrenergic receptor blocker ICI 118551 (50 μM in the bath, a). Amplitude of the holding current change evoked by 50 μM NA alone (NA) and 50 μM NA in the presence of 50 μM ICI 118551 (+ ICI 118551, b); ∗∗p < 0.01; n.s., non-significant.