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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Oct 26;27(23):5144–5148. doi: 10.1016/j.bmcl.2017.10.066

Table 1.

Effects of substitution on the aryl ring of the 3,4-dihydro-4-aryl-2(1H)-quinolinone core.

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# Ar EC50 (μM) # Ar EC50 (μM)
2 2-F,5-Br 8.3 (186%) 5c 2-F IA
5d 3-Br IA 5e 2-F,5-Cl 12 (150%)
5f 2-F,5-F IA 5g 2-F,5-CN IA
5h 2-F,5-NO2 IA 5i 2-F,5-CONH2 IA
5j 2-Cl,3-Cl IA 5k 2-Cl,4-Cl IA
5l 3-F,4-F IA 5m 3-Cl,4-Cl IA