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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Curr Opin Hematol. 2017 Jul;24(4):345–352. doi: 10.1097/MOH.0000000000000352

Figure 1. Developmental progression from HSC to immature B cell.

Figure 1

Expression of cell surface markers that define discrete stages of B cell differentiation in mouse and human are shown together with Igh and Igk gene rearrangements. The stage-specific arrest in differentiation caused by mouse genetic mutations in transcription and signaling factors is shown as red perpendicular lines on the developmental progression. Germ-line deletion of Ikzf1 arrest lymphocyte differentiation at the LMPP stage, whereas, conditional inactivation of Ikzf1 downstream of the LMPP arrests at the large pre-B stage. IKAROS deficient large pre-B cells exhibit leukemic potential upon transplantation into a NOD/SCID host. Surface phenotype of human B-ALL and its origins from the early stages of B cell differentiation are shown. Loss of IKAROS augments integrin signaling, weak stromal adhesion properties and self-renewal normally displayed by wild type large pre-B cells.