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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Curr Opin Hematol. 2017 Jul;24(4):345–352. doi: 10.1097/MOH.0000000000000352

Figure 2. Repression of niche-interactions from the HSC to the large pre-B cell.

Figure 2

Comparative analysis of genes that were previously shown to be up-regulated upon loss of IKAROS in the HSC, LMPP and large pre-B cell [23,24]. A circos diagram depicting overlap between up-regulated genes (purple connecting lines) in IKAROS deficient HSC, LMPP and large pre-B cells is shown on the left side. A heatmap of functional pathways supported by the IKAROS-repressed genes in these cell types is shown on the right side. The color intensity of the heatmap is a measure of the p-value that indicates the enrichment for a given pathway in the corresponding list of up-regulated genes provided by a given experimental condition (e.g. in HSC, LMPP or large pre-B cell)