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. 2016 Aug 16;13(6):1449–1458. doi: 10.5114/aoms.2016.61793

Table I.

Characteristics of studies of the vitamin D receptor (VDR) FokI gene polymorphism included in this meta-analysis

First author Year Ethnicity Source of control Genotyping Sample size of case Sample size of control PHWE Frequencyof f allele
ff fF FF Total ff fF FF Total
Correa 1999 Caucasian Population-based PCR-RFLP 10 58 50 118 9 42 38 89 0.598 0.337
Chokkalingam 2001 Asian Hospital-based PCR-RFLP 41 95 51 187 62 153 87 302 0.725 0.459
Tayeb 2004 Caucasian Population-based PCR-RFLP 2 10 16 28 11 24 21 56 0.391 0.411
Oakley-Girvan 2004 Caucasian Population-based PCR-RFLP 27 120 85 232 26 77 68 171 0.586 0.377
Oakley-Girvan 2004 African-American Population-based PCR-RFLP 4 25 84 113 5 42 74 121 0.752 0.215
Bodiwala 2004 Caucasian BPH-based PCR-RFLP 60 163 145 368 35 100 108 243 0.137 0.350
Cheteri 2004 Caucasian Population-based PCR-RFLP 101 247 204 552 80 234 207 521 0.305 0.378
Mishra 2005 Arabian Hospital-based PCR-RFLP 5 45 78 128 16 69 62 147 0.622 0.344
John 2005 Caucasian Population-based PCR-RFLP 69 203 153 425 57 209 171 437 0.581 0.370
Hayes 2005 Caucasian Population-based DGGE 112 359 340 811 98 322 293 713 0.526 0.363
Cicek 2006 Mixed Population-based PCR-RFLP 71 191 77 339 77 202 200 479 0.034 0.372
Huang 2006 Asian Hospital-based PCR-RFLP 87 204 125 416 119 248 135 502 0.806 0.484
Rukin 2007 Caucasian BPH-based Pyrosequencing 166 203 61 430 135 141 44 320 0.461 0.642
Mikhak 2007 Caucasian Population-based Taqman 101 337 232 670 108 310 255 673 0.398 0.391
Li 2007 Caucasian Population-based PCR-RFLP 152 475 383 1010 206 655 571 1432 0.413 0.373
Holick 2007 Caucasian Population-based SNPlex assay 100 261 222 583 85 245 222 552 0.204 0.376
Torkko 2008 Spanish Population-based Taqman 26 70 45 141 57 125 91 273 0.249 0.438
Torkko 2008 Caucasian Population-based Taqman 67 209 168 444 63 227 198 488 0.87 0.362
Holt 2009 African-American Population-based SNPlex assay 2 48 65 115 4 24 39 67 0.904 0.239
Holt 2009 Caucasian Population-based SNPlex assay 108 335 262 705 101 352 263 716 0.332 0.387
Bai 2009 Asian Hospital-based PCR-RFLP 26 63 33 122 37 55 38 130 0.08 0.496
Rowland 2013 African-American Population-based Taqman 24 161 236 421 10 90 134 234 0.287 0.235
Rowland 2013 Caucasian Population-based Taqman 193 598 406 1197 112 413 311 836 0.171 0.381
Yousaf 2014 Arabian Hospital-based PCR-RFLP 2 0 39 41 13 0 95 108 0 0.120
Atoum 2015 Arabian Population-based PCR 10 76 38 124 6 66 28 100 0 0.390

HWE – Hardy-Weinberg equilibrium of controls, RFLP – restriction fragment length polymorphism, BPH – benign prostatic hyperplasia.