Table III.
Comparison of quantitatively assessed β-catenin, E-cadherin and N-cadherin immunoexpression (% of the IHC reaction area in analysed area of liver parenchyma) in chronic hepatitis C (CH-C), hepatocellular carcinoma (HCC) and normal liver (C)
| Variable | Group | No. | Mean | Median | Min. | Max. | SD | P-value |
|---|---|---|---|---|---|---|---|---|
| β-catenin | C | 8 | 25.37 | 19.80 | 0.43 | 69.64 | 26.97 | C vs. CH-C: NS C vs. HCC: 0.020 CH-C vs. HCC: 0.005 |
| CH-C | 54 | 7.00 | 3.69 | 0.00 | 28.75 | 7.41 | ||
| HCC | 61 | 5.71 | 1.63 | 0.00 | 44.95 | 9.44 | ||
| E-cadherin | C | 7 | 9.47 | 8.23 | 0.03 | 24.73 | 9.93 | C vs. CH-C: 0.045 C vs. HCC: < 0.001 CH-C vs. HCC: < 0.001 |
| CH-C | 41 | 1.78 | 0.42 | 0.00 | 8.61 | 2.67 | ||
| HCC | 60 | 1.95 | 0.01 | 0.00 | 78.80 | 10.49 | ||
| N-cadherin | C | 8 | 1.22 | 0.69 | 0.00 | 4.04 | 1.54 | C vs. CH-C: 0.064 C vs. HCC: NS CH-C vs. HCC: NS |
| CH-C | 28 | 0.19 | 0.00 | 0.00 | 3.92 | 0.78 | ||
| HCC | 59 | 0.55 | 0.00 | 0.00 | 14.35 | 2.16 |
Min. and max. – minimal and maximal values, respectively: NS – statistically non-significant. IHC – immunohistochemical, p – level of significance, SD – standard deviation, vs. – versus.