Table IV.
Tissue expression of β-catenin, E-cadherin and N-cadherin (mean % of IHC reaction area ± SD) as related to grading and staging in chronic hepatitis C (CH-C) group
| Scoring system scale | No. | β-catenin | No. | E-cadherin | No. | N-cadherin | |
|---|---|---|---|---|---|---|---|
| Grading (G): | |||||||
| 1 | 22 | 6.99 ±6.65 | 18 | 1.73 ±2.97 | 14 | 0.10 ±0.36 | |
| 2 | 21 | 6.45 ±6.67 | 18 | 1.55 ±2.04 | 12 | 0.33 ±1.13 | |
| 3 | 11 | 8.05 ±10.34 | 5 | 2.77 ±3.83 | 2 | –1 | |
| Staging (S): | |||||||
| 0 | 2 | –1 | 1 | –1 | 1 | –1 | |
| 1 | 28 | 7.83 ±7.39 | 23 | 2.08 ±2.98 | 17 | 0.08 ±0.33 | |
| 2 | 13 | 5.34 ±4.14 | 10 | 1.01 ±1.16 | 7 | 0.56 ±1.48 | |
| 3 | 6 | 3.85 ±4.52 | 5 | 1.28 ±2.15 | 2 | –1 | |
| 4 | 5 | 12.90 ±13.78 | 2 | –1 | 1 | –1 | |
IHC – immunohistochemical, No. – number of patients
1
insufficient data for statistical evaluation, SD – standard deviation, p = 0.842 for expression of β-catenin and p = 0.702 for expression of E-cadherin between G1, G2 and G3 (Kruskal-Wallis test); p = 0.940 for expression of N-cadherin between G1 and G2 (Mann-Whitney test). In the case of β-catenin expression as related to staging 1 (S1), S2, S3, S4 – p = 0.473; for expression of E-cadherin as related to S1, S2 and S3 – p = 0.795 (Kruskal-Wallis test); for expression of N-cadherin in S1 and S2 – p = 0.756 (Mann-Whitney test).