TABLE 5.
Logistic regression model of increased iron stores (SF concentration >200 μg/L and TSAT >45%) in HEIRS women aged 25–44 y1
| OR (95% CI) | P | |
| Nonpregnant and nonbreastfeeding | ||
| HFE C282Y homozygosity | 89.4 (45.0, 177.6) | <0.001 |
| Asian American | 2.6 (1.7, 4.1) | <0.001 |
| Age, y | 1.04 (1.01, 1.07) | 0.011 |
| HFE C282Y heterozygosity | 2.0 (1.1, 3.7) | 0.020 |
| African American | 1.5 (1.0, 2.3) | 0.033 |
| Pregnant or breastfeeding, HFE C282Y homozygosity | 80.9 (14.1, 463.3) | <0.001 |
1
Logistic regression models were used to identify independent associations with measures of high iron stores. P < 0.05 was considered to be significant. HEIRS, Hemochromatosis and Iron Overload Screening; HFE, hemochromatosis gene; SF, serum ferritin; TSAT, transferrin saturation.