Table 2. Model for MRC Scale Decline in Trial-Relevant Populationa.
| Factor | Estimate (95% CI) | P Value | P Value for Heterogeneity/Interaction vs Reference Category |
|---|---|---|---|
| Estimates of Baseline and Decline | |||
| Baseline, aged 65 y | |||
| MM | 53.19 (47.82 to 58.55) | NA | NA |
| MV | 57.88 (53.85 to 61.90) | NA | .17 |
| VV | 50.89 (45.60 to 56.18) | NA | .55 |
| Per 10 y older at enrollment | −4.12 (−7.14 to −1.10) | .008 | NA |
| Decline, per d | |||
| MM | −1.90 (−2.36 to −1.45) | <.001 | NA |
| MV | −0.36 (−0.83 to 0.11) | <.001 | <.001 |
| VV | −0.76 (−1.24 to −0.28) | <.001 | <.001 |
| Estimates of Individual Variability | |||
| MM | |||
| Baseline | 17.17 (13.31 to 22.17) | NA | NA |
| Decline | 1.36 (0.95 to 1.95) | NA | NA |
| Correlation (baseline, decline) | 0.38 (0.00 to 0.66) | NA | NA |
| Residual error | 12.80 (10.91 to 15.02) | NA | NA |
| Non-MM | |||
| Baseline | 14.75 (12.52 to 17.37) | NA | NA |
| Decline | 0.33 (0.24 to 0.46) | NA | NA |
| Correlation (baseline, decline) | 0.24 (−0.02 to 0.47) | NA | NA |
| Residual error | 9.20 (8.57 to 9.87) | NA | NA |
Abbreviations: MRC, Medical Research Council; NA, not applicable.
a
Model includes 824 measurements from 154 patients with sporadic Creutzfeldt-Jakob disease and patients with fast IPD in stratum 1 with MRC Scale of 5 or greater at enrollment. Reference category aged 65 years, MM.