Table 1. Summary of general health observations in rats treated with P7C3-A20, P7C3-S321, or vehicle ±PTX.
| General health observations | VEH/VEH [n = 8] | VEH/PTX [n = 20] | A20 (20)/VEH [n = 8] |
A20 (20)/PTX
[n = 8] |
A20 (6.6)/PTX [n = 8] | A20 (2.2)/PTX [n = 8] | S321 (20)/VEH [n = 8] | S321 (20)/PTX [n = 8] | S321 (6.6)/PTX [n = 8] | S321 (2.2)/PTX [n = 8] |
|---|---|---|---|---|---|---|---|---|---|---|
| Gnawing on observation box | - | 7 | - | - | 1 | 2 | - | 1 | - | - |
| Diarrhea | - | 9 | - | 2 | 4 | 5 | - | 4 | 4 | 4 |
| Mild hair loss | - | 14 | - | 3 | 5 | 6 | - | 5 | 6 | 6 |
| Hind limb paralysis | - | - | - | - | - | - | - | - | - | - |
| Chromo-dacryorrhea | - | 10 | - | - | - | 1 | - | 1 | 1 | 3 |
| Standing/walking on ‘Tip-Toes’ | - | 17 | - | 2 | 4 | 5 | - | 2 | 5 | 5 |
| Hovering paw | - | 4 | - | - | 1 | 2 | - | - | - | 1 |
| Jump response | - | 5 | - | 1 | 2 | 2 | - | 2 | 2 | 1 |
| Death | - | 3 | - | - | - | 1 | - | 1 | 1 | 3 |
Numbers in parentheses next to the drug name indicate the daily dose in mg/kg.
Numbers in the table represent the number of rats that displayed the health indicator in the row title. “- “indicates 0 rats displayed the health indicator. Total number of rats in the group are shown in the column title row.