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Serum Stability Assay and Tm Measurement of Different SQR-SEQ Nanoparticles
(A) Serum stability of (a) 2′F SQR-SEQ2′F, (b) RNA SQR-SEQRNA, (c) DNA SQR-SEQDNA, and (d) 2′F SQR-SEQDNA assayed in 10% FBS supplemented cell culture medium. (B) Tm measurement of 2′F SQR-SEQ2′F, RNA SQR-SEQRNA, and DNA SQR-SEQDNA by temperature gradient gel electrophoresis (TGGE). Quantification analysis of intact nanoparticles % was performed by ImageJ.
